Science Daily - Heart Disease

DECEMBER 2, 2024

Eating a diet with a higher ratio of plant-based protein to animal-based protein may reduce the risk of cardiovascular disease (CVD) and coronary heart disease (CHD), according to a new study. According to the researchers, these risk reductions are likely driven by the replacement of red and processed meats with plant proteins. The researchers also observed that a combination of consuming more plant protein and higher protein intake overall provided the most heart health benefits.

Diet 112

Diet Cardiovascular Disease Heart Disease Research 112

HCPLive

DECEMBER 2, 2024

This portion of the latest Lungcast episode includes a discussion of therapies, triggers, and management of AERD.

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106

Becker's Hospital Review - Cardiology

DECEMBER 2, 2024

Salt Lake City-based Intermountain Health's St. Mary's Regional Hospital in Grand Junction, Colo., has become the first community hospital in the nation to receive vascular verification from the American College of Surgeons and the Society for Vascular Surgery.

Hospital 104

Hospital 104

Medical Xpress - Cardiology

DECEMBER 2, 2024

Eating a diet with a higher ratio of plant-based protein to animal-based protein may reduce the risk of cardiovascular disease (CVD) and coronary heart disease (CHD), according to a new study led by researchers at Harvard T.H. Chan School of Public Health. According to the researchers, these risk reductions are likely driven by the replacement of red and processed meats with plant proteins.

Public Health 100

Public Health Diet Cardiovascular Disease Heart Disease 100

Science Daily - Heart Disease

DECEMBER 2, 2024

A cancer therapy that prompts the body's immune defenses against viruses and bacteria to attack tumors can make patients more vulnerable to heart attack and stroke. A possible explanation for this side effect is that the treatment interferes with immune regulation in the heart's largest blood vessels, a new study suggests.

Cancer 100

Cancer Heart attacks Heart Attack Heart Disease 100

Journal of Clinical Investigation - Cardiology

DECEMBER 2, 2024

Metabolic dysfunction–associated steatotic hepatitis (MASH) is a chronic progressive liver disease that is highly prevalent worldwide. MASH is characterized by hepatic steatosis, inflammation, fibrosis, and liver damage, which eventually result in liver dysfunction due to cirrhosis or hepatocellular carcinoma. However, the cellular and molecular mechanisms underlying MASH progression remain largely unknown.

Diet 75

Diet 75

Science Daily - Heart Disease

DECEMBER 2, 2024

A critical review of cell-based and cell product-based therapies for the treatment of heart failure details 20 years of completed and ongoing clinical trials. While none has yet gained medical approval, pathways to new treatments for heart failure can take decades, as seen for two other, now accepted therapies.

Heart Failure 94

Heart Failure 94

American College of Cardiology

DECEMBER 2, 2024

Between 2% to 3% of all patients and 5% to 6% of all women who present with what looks like an acute coronary syndrome (ACS) are actually suffering from a peculiar and reversible acute cardiac condition, not caused by epicardial coronary obstruction, called takotsubo syndrome (TTS).

Article 73

Article 73

Medical Xpress - Cardiology

DECEMBER 2, 2024

Stress after a heart attack is understandableand new research into what drives such stress suggests that fear of another heart attack might play a significant role.

Heart attacks 70

Heart attacks Heart Attack Research 70

American College of Cardiology

DECEMBER 2, 2024

Is there a benefit to perioperative continuation of aspirin in patients with coronary drug-eluting stents (DES) undergoing noncardiac surgery?

Stents 72

Stents Stent Article 72

Medical Xpress - Cardiology

DECEMBER 2, 2024

Measuring your blood pressure at home means you can take readings over several days to get a better picture of your health, instead of one-off measurements at the doctor's clinic.

Blood Pressure 68

Blood Pressure 68

American College of Cardiology

DECEMBER 2, 2024

What is the ability of commercially available waist-high compression (WHC) garments to reduce heart rate and improve symptoms in patients with postural orthostatic tachycardia syndrome (POTS) in a community setting?

POTS 67

POTS Tachycardia Article 67

Physiologically Speaking

DECEMBER 2, 2024

Greetings! In case you missed it, here are all of the studies I covered in the November 2024 installments of the Physiology Friday newsletter. Enjoy (or re-enjoy) these summaries, and don’t forget to share them with someone you think might learn from or be interested in them. Thanks for reading! Physiologically Speaking is a reader-supported publication.

Physiology 59

Physiology Exercise Dementia Genetic predisposition 59

HCPLive

DECEMBER 2, 2024

Two supplemental Biologics License Applications for guselkumab were submitted to the FDA for treatment of children with plaque psoriasis and active juvenile psoriatic arthritis.

Plaque 65

Plaque 65

Becker's Hospital Review - Cardiology

DECEMBER 2, 2024

With deaths from obesity-related heart disease reportedly increasing by 180% over the past 20 years, more research is being done to learn how GLP-1 medications such as Ozempic, Wegovy, Mounjaro and Zepbound can address outcomes in cardiovascular health.

Outcomes 64

Outcomes Obesity Heart Disease Research 64

HCPLive

DECEMBER 2, 2024

As announced by NovelMed on December 2, 2024, the FDA has granted IND clearance for Ruxoprubart to commence an efficacy trial for the treatment of IgAN.

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American College of Cardiology

DECEMBER 2, 2024

I do not want to be a lab rat. This is what a patient who self-identified as Black told me when I attempted to obtain his approval to discuss his case and allow a physical examination during our fellowship weekly bedside teaching rounds.

Article 54

Article 54

HCPLive

DECEMBER 2, 2024

These topline findings regarding MH004, or tofacitinib etocomil ointment 1.0%, demonstrated efficacy for this twice-daily pan-Jak inhibitor in adolescents and adults with eczema.

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Medical Xpress - Cardiology

DECEMBER 2, 2024

People with high blood pressure who also lack sleep may be at increased risk of reduced cognitive performance and greater brain injury, Monash University research has found.

Blood Pressure 49

Blood Pressure Research 49

HCPLive

DECEMBER 2, 2024

The FDA affirmed the planned NDA content and format for Anaphylm expected in Q1 2025, without requiring additional adult clinical trials before submission.

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65

American College of Cardiology

DECEMBER 2, 2024

Current guidelines regarding beta-blocker use after myocardial infarction (MI) recommend against continuation to improve outcomes after 1 year, in the absence of reduced left ventricular ejection fraction (LVEF; <50%) or other primary indications for therapy.

Myocardial Infarction 49

Myocardial Infarction Outcomes Article 49

HCPLive

DECEMBER 2, 2024

Ustekinumab-kfce is planned for launch in February 2025 according to a previous settlement and license agreement with Janssen.

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65

American College of Cardiology

DECEMBER 2, 2024

Cardiovascular medicine is at a crossroads, navigating the dual pressures of an aging population and an evolving health care landscape. The business of cardiology, in particular, is being reshaped by a myriad of cultural and technological trends.

Technology 49

Technology Article 49

HCPLive

DECEMBER 2, 2024

Bob Ross, PA-C, shares expert insights on early PAD detection, updated guidelines, and practical tools to improve vascular health outcomes from CAPP 2024.

Peripheral Arterial Disease 59

Peripheral Arterial Disease Outcomes 59

American College of Cardiology

DECEMBER 2, 2024

For 75 years, the ACC has led in providing cutting-edge, innovative education to cardiovascular clinicians, ensuring they have the latest knowledge and skills to optimize patient care and outcomes. This month, Cardiology highlights three examples of ACC Education in action.

Education 49

Education Innovation Patient Care Outcomes 49

HCPLive

DECEMBER 2, 2024

Panelists discuss how misdiagnosis and delayed diagnosis of IgA nephropathy occur, highlighting the primary barriers to timely detection and strategies to overcome these challenges.

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59

Journal of Clinical Investigation - Cardiology

DECEMBER 2, 2024

The transmissible nature of prion diseases enables reproduction of neurodegeneration in small animal models that faithfully follows the disease process observed in the natural disease of animals and humans. This allows the temporal development of disease to be investigated and correlated with pathology in a complex brain environment. In this issue of the JCI, Makarava et al. describe a shift in microglia morphology from an active phagocytic phenotype to a passive association with neuronal cell b

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HCPLive

DECEMBER 2, 2024

The GLEAM trial is currently enrolling patients to receive SC291, with data expected in 2025.

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52

Journal of Clinical Investigation - Cardiology

DECEMBER 2, 2024

The cyclic GMP-AMP synthase/stimulator of interferon genes (cGAS/STING) pathway is a critical driver of type I interferon (IFN-I) and antitumor CD8+ T cell responses after radiotherapy (RT). In this issue of the JCI, two reports describe mechanisms that restrained STING signaling and abrogated antitumor immunity after RT. Wen, Wang, and colleagues discovered that IFN-I mediated the induction of YTHDF1, an RNA N6-methyladenosine–binding protein, in DCs after RT promoted cathepsin-mediated STING d

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HCPLive

DECEMBER 2, 2024

Panelists discuss how SGLT2 inhibitors, RAAS inhibitors, and GLP-1 receptor agonists differ in their treatment of chronic kidney disease (CKD) in patients with type 2 diabetes, along with strategies for managing hyperkalemia in patients to help them resume their treatment course.

Kidney Disease 52

Kidney Disease Diabetes 52

Journal of Clinical Investigation - Cardiology

DECEMBER 2, 2024

Upon RNA virus infection, the signaling adaptor MAVS forms functional prion-like aggregates on the mitochondrial outer membrane, which serve as a central hub that links virus recognition to downstream antiviral innate immune responses. Multiple mechanisms regulating MAVS activation have been revealed; however, the checkpoint governing MAVS aggregation remains elusive.

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HCPLive

DECEMBER 2, 2024

Panelists discuss how clinicians can differentiate IgA nephropathy from other glomerular diseases, such as lupus nephritis and membranous nephropathy, that may present with similar clinical features.

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Open Heart

DECEMBER 2, 2024

Introduction Heart failure with reduced ejection fraction (HFrEF) guidelines recommend ‘four pillars’ of medical therapy and device therapy if left ventricular ejection fraction (LVEF) remains ≤35% after 3 months optimum medical therapy. We conducted the first study to examine the effects of optimisation to contemporary medical therapy on cardiac reverse remodelling, as demonstrated by cardiac magnetic resonance imaging (CMR).

ACE Inhibitor 52

ACE Inhibitor Heart Failure Cardiomyopathy Outcomes 52

American College of Cardiology

DECEMBER 2, 2024

Work, practice, expense and liability relative value units (RVUs) are updated annually through the Centers for Medicare and Medicaid Services' Medicare Physician Fee Schedule (PFS) rulemaking.

Medicare 43

Medicare Medicaid Article 43

Hypertension Journal

DECEMBER 2, 2024

Hypertension, Ahead of Print. BACKGROUND:Aldosterone-producing adenomas (APAs) are a common cause of primary aldosteronism that can lead to cardiovascular complications if left untreated. Machine learning-based bioinformatics approaches have emerged as powerful tools for identifying potential disease markers, gaining widespread recognition in biomedical research.

Biomarkers 40

Biomarkers Hypertension Research 40

American College of Cardiology

DECEMBER 2, 2024

The Centers for Medicare and Medicaid Services (CMS) released the 2025 Medicare Physician Fee Schedule (PFS) final rule on Nov. 1. Of note, the 2025 PFS conversion factor is $32.3465, a reduction of 2.83% from $33.2875 in 2024.

Medicare 43

Medicare CMS Medicaid Article 43

Hypertension Journal

DECEMBER 2, 2024

Hypertension, Ahead of Print. BACKGROUND:The infiltration of macrophages into the lungs is a common characteristic of perivascular inflammation, contributing to vascular remodeling in pulmonary hypertension (PH). Peli1 (pellino E3 ubiquitin-protein ligase 1) plays a critical role in regulating the production of proinflammatory cytokines and the polarization of macrophages in various diseases.

Pulmonary 40

Pulmonary Hypertension Transplant 40