Thu.Jan 30, 2025

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Regular dental flossing may lower risk of stroke from blood clots, irregular heartbeats

Science Daily - Heart Disease

People who regularly floss their teeth (one or more times per week) may lower their risk of stroke caused by a blood clot traveling from the heart and a stroke associated with an irregular heartbeat such as atrial fibrillation (AFib).

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Online Intervention Improves Cognition

Med Page Today

(MedPage Today) -- An online intervention targeting modifiable dementia risk factors improved cognition over 3 years, a randomized controlled trial of 6,100 older adults in Australia showed. The primary outcome of change in global cognitive composite.

Dementia 124
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More Americans than ever are confident about providing lifesaving CPR, survey suggests

Medical Xpress - Cardiology

When someone's heart stops pumping, early CPR can save their life. New survey research from the American Heart Association reveals more Americans are prepared to provide that lifesaving rhythm for their friends, family and community.

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Combined Tacrolimus, Belatacept Regimen Improves Post-Kidney Transplant Outcomes

HCPLive

Findings suggest the benefits of combined belatacept and tacrolimus immunosuppression after kidney transplantation for patient and all-cause graft survival.

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Propranolol may reduce ischemic stroke risk in women with migraines

American Heart News - Stroke News

Research Highlights: Propranolol, a beta blocker medication used for treating high blood pressure and preventing migraines, may lower ischemic stroke risk in women who experience migraines frequently. In the large analysis of more than 3 million.

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Biomarker tied to premature cell aging may signal stroke, dementia, late-life depression

Science Daily - Stroke

Shorter protective caps on chromosomes called telomeres, a proposed marker of accelerated biological cell aging, may be associated with an increased risk of stroke, dementia and late-life depression, according to an analysis of more than 356,000 people in the United Kingdom.

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ECG tests may someday be used by AI model to detect premature aging and cognitive decline, say researchers

Medical Xpress - Cardiology

Electrocardiogram tests may someday be used with an artificial intelligence (AI) model to detect premature aging and cognitive decline, according to a preliminary study presented at the American Stroke Association's International Stroke Conference 2025, held in Los Angeles, Feb. 57, 2025.

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How the virus behind COVID-19 can harm your blood vessels and your heart

Medical Xpress - Cardiology

It started as a respiratory illnessor so everyone thought. But it quickly became apparent that SARS-CoV-2, the virus that causes COVID-19, was so much more.

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Palliative Care for Dementia Cuts Emergency Department Visits, Hospitalizations

HCPLive

A study found palliative care for dementia did not improve neuropsychiatric symptoms but reduced emergency visits and hospitalizations over 2 years.

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Propranolol may reduce ischemic stroke risk in women with migraines

Science Daily - Stroke

Propranolol, a beta blocker medication used for treating high blood pressure and preventing migraines, may lower ischemic stroke risk in women who experience migraines frequently.

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Stroke may increase risk of anxiety, depression and more in children

American Heart News - Stroke News

Research Highlights: Children who have had a stroke may be at higher risk for developing anxiety, depression and related physical symptoms such as headaches and stomach aches than their peers. Among the study participants, the most common age for.

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FDA Approves Meloxicam and Rizatriptan (Symbravo) for Acute Migraine With or Without Aura

HCPLive

Axsome Therapeutics announced that the FDA approved the NDA for AXS-07 to treat acute migraine with or without aura on January 30, 2025.

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JUNCTIONAL ESCAPE RHYTM

ECG Guru

In this 12-lead ECG there is a bradycardic rhythm, which is regular, heart rate about 45 bpm. The QRS complexes are narow. What is this rhythm called? There are no P waves present, and no flutter or fibrillation waves can be seen. There are 2 possibilities: 1. There is a sinus arrest with a junctional escape rhythm. The junctional rhythm either cannot conduct retrograde to the atria (therefore no inverted retrograde P wave can be seen) or the retrograde P wave is hidden in the QRS complex (atria

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ECG tests may someday be used by AI model to detect premature aging and cognitive decline

Science Daily - Stroke

An artificial intelligence (AI) model designed to predict a person's biological age (age of body cells and tissues) based on electrocardiogram (ECG)

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FDA Approves Suzetrigine, a Non-Opioid Option, for Treatment of Acute Pain

HCPLive

The FDA approval of suzetrigine, a non-opioid pain signal inhibitor, may help address the needs of patients with moderate-to-severe acute pain.

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Study suggests a common mouth and gut bacteria may be linked with increased stroke risk

Medical Xpress - Cardiology

A common bacteria usually found in the mouth and gastrointestinal tract, Streptococcus anginosis, may be abundant in the guts of people with stroke and is associated with a worse prognosis and increased risk of death, according to a preliminary study presented at the American Stroke Association's International Stroke Conference 2025, held in Los Angeles, Feb. 57, 2025.

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Stroke warning sign acronyms drive 911 calls, F.A.S.T. leads in symptom recall for public

Science Daily - Heart Disease

Both F.A.S.T. and BE-FAST acronyms motivated people to call 911 right away for a possible stroke, and this impact lasted for 30 days.

Stroke 79
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Abstract WP56: Dental Flossing associated with reduced White Matter Hyperintensity and Intracranial Atherosclerosis

Stroke Journal

Stroke, Volume 56, Issue Suppl_1 , Page AWP56-AWP56, February 1, 2025. Introduction:Prior studies have shown the association between oral infection, white matter hyperintensity (WMH), a marker of cerebral small vessel disease (CSVD), and asymptomatic intracranial atherosclerosis (ICAS). However, the impact of preventative oral behavior such as dental flossing is unknown.

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A common mouth and gut bacteria may be linked with increased stroke risk

Science Daily - Heart Disease

Increased levels of Streptococcus anginosus, a common type of bacteria that usually lives in the mouth and gut, was found in the gut of recent stroke survivors in Japan.

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Abstract TP69: Stroke Coordinator Academies: Providing Mentored Experiences for Novice Presenters

Stroke Journal

Stroke, Volume 56, Issue Suppl_1 , Page ATP69-ATP69, February 1, 2025. Background:According to AHAs Scientific Statement,Ideal Foundational Requirements for Stroke Program Development and Growth, an essential role responsibility for stroke coordinators (SC) is to optimize stroke care within their facility and the community. SCs accomplish this by designing and implementing quality improvement (QI) projects close gaps in care identified through analysis of performance data.

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Understanding Semaglutide for Diabetes and CKD, with Pranav Garimella, MBBS, MPH

HCPLive

Garimella describes the overlap between diabetes and kidney disease, explaining the significance of semaglutides new indication for these patients.

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Changing therapy practice to add higher-intensity walking improves early stroke recovery

Science Daily - Stroke

By integrating 30 minutes a day of progressive walking exercise into standard stroke rehabilitation (30 to 60 minutes of physical therapy five days a week) stroke patients had a measurable improved quality of life and mobility at hospital discharge compared to a control group.

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Blood test may detect stroke type before hospital arrival, allowing faster treatment

Science Daily - Heart Disease

People with brain bleeds had nearly 7 times higher blood levels of a specific brain protein, called glial fibrillary acidic protein (GFAP), than those who had strokes caused by clots in a study conducted in Germany.

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Diabetes Dialogue: Understanding Semaglutide (Ozempic) in CKD and T2D

HCPLive

In this episode, hosts discuss the approval of semaglutide (Ozempic) for reducing the progression of kidney disease in type 2 diabetes.

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Enzyme ALPK2: A therapeutic target for a lethal form of heart failure

Medical Xpress - Cardiology

Researchers from the Nagoya University Graduate School of Medicine identified an enzyme, alpha-kinase 2 (ALPK2) that is specifically expressed in the heart. They found that the enzyme may prevent a stiff heart through activating the gene TPM1 in heart muscle fibers. ALPK2 is a promising new therapeutic target for the treatment of heart failure, especially heart failure with preserved ejection function (HFpEF).

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Can a Factor XI Inhibitor Provide the Anticoagulation Effectiveness of DOACs for AF While Improving Safety?

NEJM Journal Watch - Cardiology

Findings from an industry-sponsored, phase 2 trial of abelacimab suggest reduced bleeding compared with rivaroxaban.

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El mantenimiento de una dieta de estilo mediterráneo mejoró la salud cerebral en un estudio de adultos hispanos y latinos

American Heart News - Stroke News

Puntos destacados de la investigacin: El seguimiento estricto de una dieta de estilo mediterrneo (rica en frutas, verduras, frijoles, aceite de oliva y algo de pescado y pollo) estuvo relacionado con una mejor salud cerebral en un estudio de adultos.

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New Tool Helps Predict Stroke Outcome with Higher Accuracy

DAIC

tim.hodson Thu, 01/30/2025 - 15:31 Jan. 29, 2025 Researchers atOchsner Health, led byHernan Bazan, MD, DFSVS, FACS, have developed a predictive model with a 93% accuracy rate in determining whether urgent carotid-intervention patients will regain functional independence. This study, Precision in Stroke Care: A Novel Model for Predicting Functional Independence in Urgent Carotid Intervention Patients, is now available in the Journal of the American College of Surgeons.

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A new therapeutic target for a lethal form of heart failure: ALPK2

Science Daily - Heart Disease

Heart failure with preserved ejection function is a lethal form of heart failure, with few effective treatments. A team has now identified an enzyme, alpha-kinase 2 (ALPK2), that is specifically expressed in the heart and regulates the heart dysfunction that leads to heart failure with preserved ejection function. ALPK2 signaling represents a potential therapeutic target.

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Merck Halts Phase 3 HYPERION Trial of Sotatercept for Final Analysis

HCPLive

Merck announced robust efficacy data on the benefit of sotatercept for PAH in the STELLAR and ZENITH studies led to a loss of clinical equipoise in HYPERION.

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Blood test may detect stroke type before hospital arrival, allowing faster treatment

Medical Xpress - Cardiology

A blood test may rapidly distinguish brain bleeds from clot-caused strokes, even before people with stroke symptoms reach the emergency room, according to a preliminary study presented at the American Stroke Association's International Stroke Conference 2025, held in Los Angeles, Feb. 57, 2025.

Stroke 59
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El propranolol podría reducir el riesgo de ataque o derrame cerebral isquémico en las mujeres con migraña

American Heart News - Stroke News

Puntos destacados de la investigacin: El propranolol, un medicamento betabloqueante que se usa para tratar la presin arterial alta y prevenir las migraas, podra reducir el riesgo de ataque o derrame cerebral isqumico en las mujeres que tienen.

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Study shows changing therapy practice to add higher-intensity walking improves early stroke recovery

Medical Xpress - Cardiology

A progressively higher-intensity walking exercise program combined with standard physical therapy significantly improved the quality of life and mobility in stroke survivors, according to a preliminary study presented at the American Stroke Association's International Stroke Conference 2025, held in Los Angeles, Feb. 57, 2025.

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Targeting gut microbiota to regulate the adaptive immune response in atherosclerosis

Frontiers in Cardiovascular Medicine

Atherosclerosis, the leading cause of death worldwide, is a chronic inflammatory disease leading to the accumulation of lipid-rich plaques in the intima of large and medium-sized arteries. Accumulating evidence indicates the important regulatory role of the adaptive immune system in atherosclerosis during all stages of the disease. The gut microbiome has also become a key regulator of atherosclerosis and immunomodulation.

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Complex high-risk indicated PCI (CHIP-PCI): is it safe to let fellows-in-training perform it as primary operators?

Open Heart

Background Training in complex high-risk indicated percutaneous coronary intervention (CHIP-PCI) has frequently been reserved for established operators (consultants/attending) with trainees (fellows-in-training or FIT) being often discouraged from carrying out such procedures as a primary operator due to their high-risk nature. Whether the outcomes of these cases differ if the primary operator is a supervised FIT compared with a consultant is unknown.

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Realheart TAH Receives Humanitarian Use Device Designation from FDA

DAIC

tim.hodson Thu, 01/30/2025 - 15:22 Jan. 29, 2025 Scandinavian Real Heart AB (recently aannouncedthat its total artificial heart, Realheart TAH, has been granted Humanitarian Use Device (HUD) designation by the U.S. Food and Drug Administration (FDA). The HUD designation makes Realheart TAH eligible to apply for Humanitarian Device Exemption (HDE), an expedited regulatory pathway that can grant the product limited marketing rights.

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Impact of porcelain aorta on outcomes in transfemoral aortic valve implantation (TAVI) with balloon-expandable valves

Open Heart

Background Current guidelines recommend transcatheter aortic valve implantation (TAVI) for patients with aortic stenosis and porcelain aorta (PA). Neurological outcomes of patients with PA undergoing TAVI with modern valves require clarification as most trials examined balloon-expandable valves (BEV) and self-expandable valves in intermediate or high-risk patients, but not specifically in patients with PA.