Study Identifies Association Between Psoriasis, Sleep Disorders in National Cohort
HCPLive
MAY 14, 2025
In this analysis, investigators looked at the extent to which psoriasis severity correlates with patients risk of developing sleep disorders.
Wed.May 14, 2025
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Backup Drug Gains Footing for Resistant Hypertension
Med Page Today
MAY 14, 2025
(MedPage Today) -- A diuretic was able to match spironolactone for blood pressure (BP) lowering in people with resistant hypertension, a small randomized trial showed. Home-measured systolic blood pressure (SBP) was similarly reduced at 12 weeks.
Could a mini-stroke leave lasting fatigue?
Science Daily - Stroke
MAY 14, 2025
A transient ischemic attack, also known as a mini-stroke, is typically defined as a temporary blockage of blood flow to the brain that causes symptoms that go away within a day, but a new study finds that people who have this type of stroke may also have prolonged fatigue lasting up to one year.
Can Lamin Dilated Cardiomyopathy Be Identified Earlier?
American College of Cardiology
MAY 14, 2025
Cardiovascular magnetic resonance (CMR) imaging was able to detect longer myocardial T2, higher extracellular volume (ECV) fraction and worse myocardial dynamics, including impaired strain, before significant decline in left ventricular (LV) systolic function in carriers of LMNA (Lamin) dilated cardiomyopathy (DCM).
Bridging Innovation & Patient Care: The Growing Role of AI
Speaker: Simran Kaur, Co-founder & CEO at Tattva.Health
AI is transforming clinical trials—accelerating drug discovery, optimizing patient recruitment, and improving data analysis. But its impact goes far beyond research. As AI-driven innovation reshapes the clinical trial process, it’s also influencing broader healthcare trends, from personalized medicine to patient outcomes. Join this new webinar featuring Simran Kaur for an insightful discussion on what all of this means for the future of healthcare!
Type 1 Diabetes Diagnosed in Adulthood Heightens Cardiovascular Risk
HCPLive
MAY 14, 2025
Adult-onset T1D significantly raises cardiovascular disease and mortality risks, highlighting the need for improved management and prevention strategies.
Diagnostic value and clinical impact of cardiac magnetic resonance imaging in patients after sudden cardiac arrest: a retrospective study
Open Heart
MAY 14, 2025
Introduction Cardiac MRI (CMRI) is an important investigation in cases of unclear cause of sudden cardiac arrest (SCA). It demonstrates diagnostic utility in assessing reversibility and tissue scar burden and ultimately aids in further treatment planning. Methods A retrospective analysis of all adult patients referred for CMRI after SCA between 2007 and 2022 by local intensive care units in our institution was performed.
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Persistent Mucus Plugs Associated With Faster Lung Decline in COPD
HCPLive
MAY 14, 2025
New research follows a previous landmark study that linked mucus plugs to increased mortality in people with COPD even without hallmark symptoms.
Exploring the role of the atherogenic index of plasma as a mediator between body roundness Index and cardiovascular events in older adults: a NHANES-based study
Frontiers in Cardiovascular Medicine
MAY 14, 2025
BackgroundThe rising incidence of cardiovascular diseases (CVD) in the elderly highlights the need for effective preventive strategies. Recent studies suggest that obesity, through metabolic factors, contributes to the development of CVD. This study aims to explore how body roundness index (BRI) levels affect the occurrence of CVD using data from the National Health and Nutrition Examination Survey (NHANES) (20032016), to better understand the role of obesity in CVD prevention and management.Met
New study finds that tea and chocolate may help lower blood pressure
Science Daily - Heart Disease
MAY 14, 2025
We might have another reason to enjoy our daily cup of tea or small piece of dark chocolate, as a new study has found that naturally occurring compounds called flavan-3-ols -- found in cocoa, tea, apples and grapes -- may improve blood pressure and the health of our blood vessels.
Xenotransplantation — Long Awaited, Much Learned, Much More to Be Learned
The New England Journal of Medicine
MAY 14, 2025
Despite vigorous efforts to expand the transplantation of organs from deceased and living donors, the gap between supply and demand persists. This lack of available organs has become a major factor in limiting the lifesaving potential of organ transplantation. Xenotransplantation, which has been hailed as the ultimate solution, seemed mirage-like.
An experimental immunotherapy reverses heart energy damage caused by cholesterol
Medical Xpress - Cardiology
MAY 14, 2025
An international team of researchers has discovered how cholesterol can disrupt the internal functioning of the heart by accumulating in the mitochondria of cardiomyocytes. They have also developed an experimental immunotherapy capable of reversing this process and restoring cellular energy production.
Nonlinear Relationship Between Left Atrial Volume Measured by Computed Tomography and Recurrent Atrial Arrhythmias in Patients Undergoing Catheter Ablation for Atrial Fibrillation
Journal of Cardiovascular Electrophysiology
MAY 14, 2025
ABSTRACT Background Left atrial remodeling is commonly believed to contribute to the recurrence of atrial arrhythmias following catheter ablation for atrial fibrillation (AF). However, the relationship between left atrial volume (LAV) assessed via left atrial computed tomography (LACT) and AF recurrence remains insufficiently explored. Aim This study aimed to examine the association between LAV measured by LACT and the recurrence of AF.
High Mortality and Complications in Patients Admitted With Takotsubo Cardiomyopathy With More Than Double Mortality in Men Without Improvement in Outcome Over the Years
Journal of the American Heart Association
MAY 14, 2025
Journal of the American Heart Association, Ahead of Print. BackgroundTakotsubo cardiomyopathy continues to be a major cause of mortality and morbidity. The goal of this study was to evaluate the outcome data of patients with Takotsubo cardiomyopathy using a large inpatient database.Methods and ResultsWe used the Nationwide Inpatient Sample database for our study.
SNAP shields kids from future heart disease risks, long-term study finds
Medical Xpress - Cardiology
MAY 14, 2025
Experiencing food insecurity in early childhood is associated with worse heart health two decades later, especially higher Body Mass Index (BMI). But participation in the Supplemental Nutrition Assistance Program (SNAP) may significantly mitigate that risk, reports a long-term Northwestern Medicine study published in JAMA Cardiology.
New insights into the energy balance of brain neurons
Science Daily - Stroke
MAY 14, 2025
A research team has demonstrated how the energy levels of individual neurons in the brain change during so-called spreading depolarizations -- waves of activity that occur in various brain disorders. The findings provide important foundations for understanding energy metabolism in cases of acute cerebral ischaemia, such as that which occurs during a stroke.
3D reconstructions of cat hearts can shed light on human blood clot risks while reducing need for animal experimentation
Medical Xpress - Cardiology
MAY 14, 2025
Pompeu Fabra University (UPF) and the Royal Veterinary College of London have worked together on a pioneering project worldwide to generate 3D reconstructions of the hearts of different animals and simulations of their blood flow using advanced computational techniques to date only applied to humans. So far, 3D images of cats' hearts have been generated, but soon the same will be done for dogs, pigs and sheep.
MRI scans could help detect life-threatening heart disease
Science Daily - Heart Disease
MAY 14, 2025
Magnetic resonance imaging (MRI) scans of the heart could help to detect a life-threatening heart disease and enable clinicians to better predict which patients are most at risk, according to a new study.
Speaking more than one language can add layers to stroke recovery
Medical Xpress - Cardiology
MAY 14, 2025
You might not put a lot of thought into what it takes to speak, but speaking keeps your brain busy. In every conversation, multiple regions activate to process sounds, give words meaning and control the muscles that move your mouth.
A validated multivariable machine learning model to predict cardio-kidney risk in diabetic kidney disease
Cardiovascular Diabetology
MAY 14, 2025
Individuals with diabetic kidney disease (DKD) often suffer cardiac and kidney events. We sought to develop an accurate means by which to stratify risk in DKD.
Could a mini-stroke leave lasting fatigue?
Medical Xpress - Cardiology
MAY 14, 2025
A transient ischemic attack, also known as a mini-stroke, is typically defined as a temporary blockage of blood flow to the brain that causes symptoms that go away within a day, but a new study finds that people who have this type of stroke may also have prolonged fatigue lasting up to one year.
Raising the bar in Interventional Cardiology: Highlights from the CTO & Complex PCI Training
ADN Center of Excellence
MAY 14, 2025
What does happen when world-renowned cardiologists, a master educator, and a unique agenda are combined for two consecutive days? You do not receive another workshop, you receive an experience that will transform you. Our CTO and Complex PCI course, which was conducted on 1314 May 2025 at ADN CoE, was not just an event.
Dyspnea , Is it from the heart or lungs ? : A land mark paper in Internal medicine, JAMA 1982.
Dr. S. Venkatesan MD
MAY 14, 2025
Dyspnea is one of the commonest symptoms in medical practice. Whatever be the trigger, ultimately, it is a sensory perception, felt at the level of the cortex (to be specific, the Amygdala nucleus) decides the intensity. The initiating receptor usually arises from the muscle spindles , due to mismatch in the length and tension. These spindles are located widespread in intercostal and other respiratory muscles.
Experts highlight key steps to reduce stroke risk during awareness month
Medical Xpress - Cardiology
MAY 14, 2025
May is National Stroke Awareness Month, and as part of everyday awareness, Mayo Clinic health care professionals suggest reducing stroke risk and knowing the signs. A stroke happens every 40 seconds in the U.S., and the likelihood of stroke increases with age, according to the National Institutes of Health.
Exercise-induced dysregulation of the adrenergic response in a mouse model of PKP2-arrhythmogenic cardiomyopathy
HeartRhythm
MAY 14, 2025
Plakophilin-2 (PKP2) is a component of the desmosome. Pathogenic variants can lead to arrhythmogenic cardiomyopathy (PKP2-ACM). In PKP2-ACM patients, exercise and catecholamine surges negatively impact arrhythmia incidence and severity.
MRI scans could help detect life-threatening heart disease
Medical Xpress - Cardiology
MAY 14, 2025
Magnetic resonance imaging (MRI) scans of the heart could help to detect a life-threatening heart disease and enable clinicians to better predict which patients are most at risk, according to a new study led by UCL (University College London) researchers.
Multicenter Experience of Catheter Ablation for Atrial Fibrillation in Sickle Cell Anemia
Journal of Cardiovascular Electrophysiology
MAY 14, 2025
ABSTRACT Introduction Adult patients with sickle cell anemia (SCA) are at high risk for atrial arrhythmias; however, data on the outcomes of atrial fibrillation (AF) ablation in this population are scarce. Methods and Results Eight consecutive SCA patients undergoing AF ablation in three tertiary ablation centers were retrospectively included (6 males, mean age 469 years).
Safety of Ultrasound‐Enhancing Agents: Gazing Backward While Looking Forward
Journal of the American Heart Association
MAY 14, 2025
Journal of the American Heart Association, Ahead of Print.
Electrocardiographic Characteristics of Ventricular Arrhythmias Originating From High Right Ventricular Outflow Tract and Pulmonary Artery
Journal of Cardiovascular Electrophysiology
MAY 14, 2025
ABSTRACT Background Ventricular arrhythmias (VAs) may originate from the right ventricular outflow tract (RVOT) below the pulmonary sinus cusps (PSCs) or from the pulmonary artery (PA) above the PSCs. However, the electrocardiographic (ECG) characteristics of these VAs are not well defined. Objective This study aimed to investigate the ECG characteristics of VAs originating from the high RVOT and PA.
MRI Predictors of Cognitive Function After Lacunar Infarction
Stroke Journal
MAY 14, 2025
Stroke, Ahead of Print. BACKGROUND:Poststroke cognitive impairment is associated with disability and decreased quality of life. We assessed whether individual or collective magnetic resonance imaging (MRI) biomarkers can aid in predicting cognitive impairment after lacunar infarction (LACI).METHODS:We conducted a retrospective analysis of data from the American Stroke Association Bugher Small Vessel Study, which included 134 patients within 2 years of an acute LACI, enrolled between 2007 and 201
Role of the Renin-Angiotensin System in Blood Pressure Regulation in Smooth Muscle-Specific Cullin-3 Deficient Mice
Hypertension Journal
MAY 14, 2025
Hypertension, Ahead of Print. BACKGROUND:Selective ablation of CUL3 (Cullin-3) in vascular smooth muscle cell-selective CUL3 knockout (S-CUL3KO) results in severe hypertension with paradoxically unaltered ANG II (angiotensin II) levels, suggesting an increase in ANG II sensitivity. We hypothesized that the hypertension and vascular dysfunction in S-CUL3KO mice are mediated by an exaggerated calcium response to ANG II in vascular smooth muscle cells.METHODS:Blood pressure was measured by radiotel
Interesting Cause of Pseudopleural Effusion: Giant Left Atrium
Circulation: Cardiovascular Imaging
MAY 14, 2025
Circulation: Cardiovascular Imaging, Ahead of Print.
Diastolic Perfusion Pressure Predicts Response to Inotropes and Vasopressors and Benefit From Mechanical Circulatory Support in Cardiogenic Shock
Circulation: Heart Failure
MAY 14, 2025
Circulation: Heart Failure, Ahead of Print. BACKGROUND:Hemodynamic response to escalation of vasoactive drugs has not been well-characterized in patients with cardiogenic shock (CS). We tested the hypothesis that lower diastolic perfusion pressure (DPP=diastolic blood pressureright atrial pressure) was associated with more limited hemodynamic response to uptitration of vasoactive drugs and with possible benefit from early mechanical circulatory support in patients with CS.METHODS:This study cons
Periaortic Fat Attenuation on Nongated Noncontrast Chest CT Images to Assess Changes in Arterial Inflammation: Impact of Atorvastatin
Circulation: Cardiovascular Imaging
MAY 14, 2025
Circulation: Cardiovascular Imaging, Ahead of Print. BACKGROUND:Imaging markers of atherosclerotic inflammation are needed to enhance cardiovascular risk assessment and evaluate the impact of therapies. We sought to test the hypothesis that treatments impacting arterial inflammation can be evaluated using a simplified measure of periaortic fat attenuation (FA) assessed on noncontrast, nongated computed tomography (CT) of the descending thoracic aorta.METHODS:Measurements were performed on18F-flu
Comparison of Coronary Physiological Indices in Identifying Functionally Significant Myocardial Bridges in ANOCA
Circulation: Cardiovascular Interventions
MAY 14, 2025
Circulation: Cardiovascular Interventions, Ahead of Print. BACKGROUND:A functionally significant myocardial bridge (MB) is an important cause of angina with nonobstructive coronary arteries. However, distinguishing a functionally significant versus incidental MB remains challenging. Resting and hyperemic intracoronary functional indices are available, but no studies have compared their diagnostic performance in MBs.METHODS:We prospectively studied 64 patients with angina and nonobstructive coron
Proximal native vessel disease progression : Is it good or bad following CABG ?
Dr. S. Venkatesan MD
MAY 14, 2025
No doctor will want any disease to progress in their patients. But, coronary revascularization is an enigma. Cardiologists take every step to regress the atherosclerotic process and be meticulous in maintaining antegrade flow across the left main and proximal LAD or LCX. They double up their caution after PCI in left main or proximal segments. Meanwhile, our cardiac surgeons do enjoy a unique liberty.
Ventricular Tachycardia Ablation in Patients With Severely Decreased Left Ventricular Ejection Fraction
Journal of Cardiovascular Electrophysiology
MAY 14, 2025
ABSTRACT Background Ablation of ventricular tachycardia (VT) is often performed in patients with structural heart disease. Procedural and delayed enhancement cardiac magnetic resonance imaging (DE-CMR) characteristics among patients with very severe cardiomyopathy (CM) andwithout left-ventricular assist devices (LVAD) have been incompletely described.
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