Fri.Jan 24, 2025

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Light-activated ink developed to remotely control cardiac tissue to repair the heart

Medical Xpress - Cardiology

Researchers from Mass General Brigham and collaborating institutions have developed a non-invasive approach to manipulate cardiac tissue activity by using light to stimulate an innovative ink incorporated into bioprinted tissue. Their goal is to develop a technique that can be used to repair the heart. Their findings in preclinical models, published in Science Advances, show the transformative potential of non-invasive therapeutic methods to control electrically active tissues.

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Should we wait for troponin when the ECG does not show "diagnostic" ST Elevation?

Dr. Smith's ECG Blog

Written by Willy Frick A 52 year old man with hypertension, dyslipidemia, and seropositive rheumatoid arthritis (a risk factor for CAD) presented with acute substernal chest pressure with diaphoresis which woke him from sleep just after midnight. He said it felt like "someone ripped [his] heart out." Ominous. While walking into the ED, the patient had an episode of "dizziness" causing him to fall onto his stomach.

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Drug shows promise in preventing heart failure post-heart attack in mice

Medical Xpress - Cardiology

A specially designed drug prevented laboratory mice from developing heart failure after heart attacks, according to new research from Cedars-Sinai. This discovery could lead to new treatments to prevent heart failure, a serious cardiac condition that develops in up to 30% of heart attack survivors within one year.

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Thyroid Cancer Diagnoses Rise in First Year of GLP-1 RA Use

HCPLive

GLP-1 RA initiation boosted new thyroid cancer diagnoses, compared with other anti-diabetic drugs, but enhanced early detection may have played a role.

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Symptoms of viral influenza, COVID-19, norovirus, and RSV can be signs of potential heart complications, warn experts

Medical Xpress - Cardiology

With a recent surge in influenza, COVID-19, norovirus, respiratory syncytial virus (RSV), and other respiratory viruses, it's critical to pay close attention to your heart and symptomsespecially if you have heart disease or the risk factors for it. That's the message from experts at Mount Sinai Fuster Heart Hospital during American Heart Month.

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FDA Recalls First Aid Beauty Face Moisturizers Sold in US

HCPLive

This class 2 recall by FDA officials of almost 3000 First Aid Beauty brand face moisturizers resulted from deviation from Current Good Manufacturing Practice regulations.

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ECG Blog #466 — Do You See What I See?

Ken Grauer, MD

I was sent the ECG in Figure-1 without clinical information. I interpreted the rhythm as AFib ( A trial F ibrillation ). QUESTION: Do you see anything else? Figure-1: The initial ECG in today's case. Take another LOOK. To facilitate description I've numbered the beats in Figure-2. Figure-2: I've numbered the beats from Figure-1. Confession: I initially looked at this tracing too quickly.

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Are Certain Adverse Pregnancy Outcomes Associated With Long-Term Increased Risk of HF?

American College of Cardiology

Women who experienced any of five major adverse pregnancy outcomes have increased risk of heart failure (HF) up to 46 years later and need early preventive actions and long-term clinical care to reduce that risk.

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Physiology Friday #254: Fueling for Performance and Health: Lessons from a Recent Low-Carb vs. High-Carb Study in Athletes

Physiologically Speaking

Greetings! Welcome to the Physiology Friday newsletter. Details about the sponsors of this newsletter including FSTFUEL electrolytes, Examine.com , and my book “VO2 Max Essentials ” can be found at the end of the post. You can find more products I’m affiliated with on my website. Physiologically Speaking is a reader-supported publication.

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Researchers map the brain's self-healing abilities after stroke

Science Daily - Stroke

A new study sheds light on one of the most severe consequences of stroke: damage to the brain's 'cables'-- the so-called nerve fibers -- which leads to permanent impairments.

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E-Cigarettes at the Supreme Court — Potential Implications for the FDA and Public Health

The New England Journal of Medicine

The Supreme Court recently agreed to hear a case about adolescent e-cigarette use and the FDAs role in addressing it. A ruling against the FDA could have implications for its authority and for public health.

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GOLD 2025 Report: Lung Microbiome and Chest CT Imaging in COPD

HCPLive

Panelists discuss how dysbiosis of the lung microbiome can exacerbate chronic obstructive pulmonary disease (COPD) through increased inflammation and altered immune responses. In contrast, chest CT imaging is indicated for patients with severe COPD, suspected comorbidities, surgical planning, or unexplained symptoms despite standard treatment. These factors highlight the complexity of COPD management.

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Surgeon Preference Impacts Survival Outcomes Analyses for CABG Patients

DAIC

tim.hodson Fri, 01/24/2025 - 11:51 Jan. 24, 2025 In-patients undergoing coronary artery bypass grafting (CABG), a novel analysis evaluating surgeon preference for multi- versus single-arterial grafting may help explain the differing results between prior retrospective analyses and randomized controlled trials regarding long-term survival. A study presented at The Society of Thoracic Surgeons 61st Annual Meeting explores findings in more than a million U.S.

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Tezepelumab Fails Study Endpoint of Reducing Moderate-to-Severe COPD Exacerbations

HCPLive

However, subgroup analyses may reveal a more pronounced effect in people with severe COPD.

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Study Shows Abelacimab Significantly Reduced Bleeding vs. Standard DOAC

DAIC

tim.hodson Fri, 01/24/2025 - 11:03 Jan. 22, 2025 Anthos Therapeutics, Inc., aclinical-stage biopharmaceutical company developing therapies to treatcardiovascular metabolic diseases, founded by Blackstone Life Sciences, has published the results of the landmark AZALEA-TIMI 71 study in the January 23 issue of the New England Journal of Medicine (NEJM).

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Subcutaneous Amycretin Yields Promising Weight Loss in Phase 1b/2a Trial

HCPLive

Subcutaneous amycretin achieved up to a 22.0% weight loss over 36 weeks, with a consistent safety profile to other incretin-based therapies.

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Abelacimab Stops Bleeding, But Stroke Impact Uncertain

CardiacWire

Fully published results from Athos Therapeutics AZALEA-TIMI 71 trial for its novel Factor XI inhibitor abelacimab, confirming the drugs lower bleeding risks, but leaving researchers uncertain about its ability to prevent stroke in AFib patients. Current guidelines recommend direct-acting oral anticoagulants (DOACs) for AF because they reduce ischemic stroke with a lower risk of brain hemorrhage.

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Psoriatic Arthritis Care Priorities Differ Between Patient and Clinicians

HCPLive

Delphi exercises revealed concordance between prioritized areas but also notable differences.

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CABG or PCI ? : Think beyond revascularisation guidelines & the evidence base

Dr. S. Venkatesan MD

Wars and scientific debates do not end that easily. Parallel to the Vietnam war days of 1970s to the current Ukraine-Russia conflict of 2025, one silent academic war is going on, in the conflict-ridden corridors of cardiology and cardiac surgery. (The CASS study of 1970s to the ORBITA era of 2025) Any amount of scientific literature, debates, guidelines, failed to tick the right choice of revascularisation in chronic CAD.

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Poor Allergic Rhinitis Symptoms in Air Conditioning May Predict Greater Severity

HCPLive

A new study showed that experiencing worsened allergic rhinitis symptoms in air-conditioned environments may predict disease severity.

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Does OUFR With Combined IVUS-OCT Improve Diagnostic Accuracy of Vessel Lesions?

American College of Cardiology

Assessment of vessel lesions using optical ultrasonic flow ratio (OUFR) based on hybrid intravascular ultrasound-optical coherence tomography (IVUS-OCT) is safe and effective and provided better diagnostic performance vs. fractional flow reserve (FFR) than OUFR based on either IVUS or OCT alone.

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Impacts of Dandruff Reduction on Patients’ Physical, Emotional Well-Being

HCPLive

The results of this analysis point to the significance of emotions in the treatment and functional outcomes of those with dandruff.

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Study Finds Ozone Pollution Exposure Induces Hypoxia and Contributes to CV Injury

American College of Cardiology

Short-term exposure to ozone (O3) pollution may reduce oxygen availability, prompting compensatory increases in red blood cell count (RBC) and hemoglobin (HGB), which exacerbate arterial stiffness, according to a study published Jan. 22 in JACC.

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AGA Releases Clinical Practice Update on HBV Reactivation Prevention, Treatment

HCPLive

The updated clinical practice guideline addresses new research and clinical developments since the first iteration of the guideline was released in 2014.

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Left Atrial Appendage Occlusion & Stroke, Hypertrophic Cardiomyopathy in Children, Anticoagulation & COVID-19

American College of Cardiology

In this weeks View, Dr. Eagle looks at left atrial appendage occlusion for stroke prevention in patients with AFib. He then discusses a new treatment for severe hypertrophic cardiomyopathy in children. Finally, Dr. Eagle explores anticoagulation for patients who are hospitalized with COVID-19.

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1/4 of Pediatric Liver Transplant Recipients Experience Early Hospital Readmission

HCPLive

Factors associated with 30-day readmission were shorter hospital stays after transplant, insurance status, and patient history of diabetes and malignancy.

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A Nomogram utilizing ECG P-wave parameters to predict recurrence risk following catheter ablation in paroxysmal atrial fibrillation

Journal of Cardiothoracic Surgery

Abnormal changes in P-wave parameters indicative of atrial electrical remodeling often manifest earlier than changes in other indicators reflecting atrial structural remodeling in paroxysmal atrial fibrillation.

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First Aid Beauty Face Moisturizers Sold in US Voluntarily Recalled

HCPLive

This class 2 recall of almost 3000 First Aid Beauty brand face moisturizers resulted from deviation from Current Good Manufacturing Practice regulations.

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The Secret to Weight Loss: Understanding Carbohydrates.

Dr. Paddy Barrett

I am a fan of using low-carb diets for both weight loss and improving metabolic health. Low-carb diets have consistently shown benefits in improving these parameters 1. Over the last few years, it seems, according to most social media, that if you are not going ‘Low Carb, ’ you are seriously risking your health. But Let Me Tell You A Story.

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Impact of Age on Aortic Valve Replacement Choices in Low-Risk Patients

Society of Thoracic Surgeons - Congenital

At STS 2025, Dr. Tomaz Mesar presented a study comparing outcomes of TAVR and SAVR in low-risk patients with aortic stenosis.

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Enhancing Patient Outcomes: A New Approach to Risk Adjustment and Center Performance Evaluation

Society of Thoracic Surgeons - Adult Cardiac

At STS 2025, Dr. Sharon-Lise Normand presented a session on Improving Risk Adjustment in the Assessment of Congenital Heart Center Surgical Quality.

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The impact of type 2 diabetes on left ventricular function in hypertensive patients: a three-dimensional speckle-tracking imaging study

Frontiers in Cardiovascular Medicine

ObjectivesThe study aimed to evaluate the impact of the co-occurrence of hypertension and type 2 diabetes mellitus (T2DM) on the deterioration of left ventricular (LV) structure and function using three-dimensional speckle-tracking imaging (3D-STI), compared to patients with only hypertension.MethodsData from 272 hypertensive patients, including 85 with T2DM and 187 without, along with 45 normal controls, were analyzed.

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Paradoxical Post-Tadalafil Cerebral Vasoconstriction Causing Transient Ischemic Attack

Stroke Journal

Stroke, Ahead of Print.

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Snare‐Assisted Flexion of 27‐French Leadless Pacemaker Delivery Sheath: A Case Report

Journal of Cardiovascular Electrophysiology

ABSTRACT Introduction A leadless pacemaker (LLPM) was recommended for a patient with intermittent complete heart block and near-syncope. Methods and Results Delivery of LLPM is through a large sheath that has limited deflection and steerability. This report describes the successful deployment of a ventricular LLPM in a patient with prior surgical correction of AV septal defect with subsequent significant right atrial enlargement.

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The Kidney-Immune-Brain Axis: The Role of Inflammation in the Pathogenesis and Treatment of Stroke in Chronic Kidney Disease

Stroke Journal

Stroke, Ahead of Print. Cardiovascular diseases such as stroke are a major cause of morbidity and mortality for patients with chronic kidney disease (CKD). The underlying mechanisms connecting CKD and cardiovascular disease are yet to be fully elucidated, but inflammation is proposed to play an important role based on genetic association studies, studies of inflammatory biomarkers, and clinical trials of anti-inflammatory drug targets.

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Effects of In Vivo Contact Force on Pulsed‐Field Ablation Efficacy in Porcine Ventricles

Journal of Cardiovascular Electrophysiology

ABSTRACT Background Pulsed-field ablation (PFA) is an innovative non-thermal method for arrhythmia treatment. The efficacy of various PFA configurations in relation to contact force (CF) has not been well-studied in vivo. Objectives This study evaluated the effect of CF on acute bipolar PFA lesions in both a vegetal and an in vivo porcine heart model.

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Putting the Cart Before the Horse: Intravascular Imaging as a Performance Measure

Circulation: Cardiovascular Interventions

Circulation: Cardiovascular Interventions, Ahead of Print.