Wed.Jan 08, 2025

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Exposure to aircraft noise linked to worse heart function

Science Daily - Heart Disease

People who live close to airports and are exposed to high aircraft noise levels could be at greater risk of poor heart function, increasing the likelihood of heart attacks, life-threatening heart rhythms and strokes, according to a new study.

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Sleep Month in Review: December 2024

HCPLive

This Month in Review captures 7 sleep medicine news, including FDA updates, from December 2024.

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CPR coach training boosts coach presence on code teams in pediatric ICU

Medical Xpress - Cardiology

Coach presence on code teams is significantly increased following a quality cardiopulmonary resuscitation (CPR) coach training intervention within a pediatric intensive care unit, according to a study published in the American Journal of Critical Care.

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Polypill Therapy Cost-Effective for CVD Risk in Underserved Populations

HCPLive

An economic analysis highlights a cardiovascular polypill's potential to lower healthcare costs and address income-based health disparities.

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Varipulse Heart Device Procedures Paused After Safety Events

Med Page Today

(MedPage Today) -- Just months after FDA approval, Johnson & Johnson paused the rollout of its Varipulse pulsed field ablation (PFA) platform in the U.S. due to safety reasons. In a U.S. external evaluation cohort, four reported neurovascular.

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Second pig heart transplant patient offers vital lessons

Medical Xpress - Cardiology

Continuing significant advancements in the field of xenotransplantation, surgeon-scientists from the University of Maryland School of Medicine provided an extensive analysis on the second patient in the world to receive a genetically-modified pig organ.

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Chlorthalidone vs. Hydrochlorothiazide for Hypertension: Renal Outcomes

NEJM Journal Watch - Cardiology

In a secondary analysis from a randomized trial, no important differences were noted.

More Trending

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Left Ventricular Assist Device Therapy in Cold and Dry Patients

Circulation: Heart Failure

Circulation: Heart Failure, Ahead of Print. BACKGROUND:Patients with end-stage heart failure and low pulmonary capillary wedge pressure are referred to as cold and dry and represent an understudied minority in whom the benefit of left ventricular assist device (LVAD) therapy is unclear.METHODS:Adults receiving LVADs between 2006 and 2017 in the Interagency Registry for Mechanically Assisted Circulatory Support database were classified as cold and wet (pulmonary capillary wedge pressure >1

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Late-gadolinium enhancement predicts appropriate device therapies in non-ischemic recipients of primary prevention implantable cardioverter-defibrillators

HeartRhythm

Better risk stratification is needed to evaluate patients with non-ischemic cardiomyopathy (NICM) for prophylactic implantable cardioverter-defibrillators (ICD). Growing evidence suggests cardiac magnetic resonance imaging (CMR) may be useful in this regard.

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Exposure to aircraft noise linked to worse heart function

Medical Xpress - Cardiology

People who live close to airports and are exposed to high aircraft noise levels could be at greater risk of poor heart function, increasing the likelihood of heart attacks, life-threatening heart rhythms and strokes, according to a study led by UCL (University College London) researchers.

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Evolution of Imaging Techniques in Ischemic Stroke

Stroke Journal

Stroke, Ahead of Print.

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Building digital twins and hearts: New technology could predict various health outcomes

Medical Xpress - Cardiology

Imagine having a digital carbon copy of yourself that physicians could use to predict long-term risks for disease, assess how your body may respond to treatment, and simulate surgeries in advance. A virtual twin may sound as far-fetched as robotic surgery and self-driving cars once did, but researchers are studying how to turn this vision into a reality.

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Epicardial Substrate Ablation in Symptomatic Brugada Syndrome Patients: An Updated Systematic Review and Single-arm Meta-analysis

HeartRhythm

Brugada syndrome (BrS) is a genetic heart disease that predisposes individuals to ventricular arrhythmias and sudden cardiac death. Although implantable cardioverter-defibrillators (ICDs) and quinidine are primary treatments, recurrent BrS-triggered ventricular arrhythmias can persist. In this setting, epicardial substrate ablation has emerged as a promising alternative for symptomatic patients.

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Calming chaotic waves with small electrical intervention: Researchers develop technique to stop irregular heartbeats

Medical Xpress - Cardiology

Researchers from Durham University have made an exciting discovery that could improve how doctors treat dangerous heart rhythms, like those seen in cardiac arrest.

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AI-ECG’s 2025 Kickoff

CardiacWire

The buzz around artificial intelligences impact on cardiology keeps growing louder, and thats proving to be particularly true in the AI-ECG segment, with 2025 already off to a strong start from ECG startups and researchers alike. AI and ECG pair well due to the strong pattern recognition that machine learning algorithms can achieve. This AI-ECG pairing is bringing the modality into a wider range of diseases and allowing integration with new device form factors.

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The Extravascular Implantable Cardioverter-Defibrillator: A Promising Novel Device

American College of Cardiology

Transvenous implantable cardioverter-defibrillators (ICDs) are the reference standard for preventing sudden cardiac death (SCD) but have risks associated with intravascular lead placement.

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Heart Failure with Preserved Ejection Fraction

The New England Journal of Medicine

Heart failure with preserved ejection fraction is noted for symptoms of heart failure, LVEF of at least 50%, and cardiac or structural abnormalities. Treatment includes diuretics and SGLT2 inhibitors.

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Alcohol-Associated Liver Disease, MASLD Drive Growing Liver Cancer Burden in the US

HCPLive

From 2000 to 2021, primary liver cancer incidences and deaths in the US increased by more than 100%, driven by rapid growth in ALD and MASLD.

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Transcatheter Valve Replacement in Severe Tricuspid Regurgitation

The New England Journal of Medicine

In a randomized trial involving patients with severe tricuspid regurgitation, transcatheter tricuspid-valve replacement was superior to medical therapy at 1 year.

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Mortality and Comorbidities with COPD

HCPLive

Panelists discuss current statistics indicating that COPD is one of the top three leading causes of death worldwide, with high morbidity and mortality rates, particularly in individuals over 40 years of age, and a growing global burden due to risk factors like smoking and air pollution.

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Development and validation of a prediction model for coronary heart disease risk in depressed patients aged 20 years and older using machine learning algorithms

Frontiers in Cardiovascular Medicine

BackgroundDepression is being increasingly acknowledged as an important risk factor contributing to coronary heart disease (CHD). Currently, there is no predictive model specifically designed to evaluate the risk of coronary heart disease among individuals with depression. We aim to develop a machine learning (ML) model that will analyze risk factors and forecast the probability of coronary heart disease in individuals suffering from depression.MethodsThis research employed data from the Nationa

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C-Reactive Protein Effective as Biomarker for HS Treated with Adalimumab

HCPLive

Patients in this post-hoc analysis with elevated CRP were found to have a higher BMI and more severe hidradenitis suppurativa.

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Key Updates in the 2025 American Diabetes Association (ADA) Diabetes Guidelines 

Cardiometabolic Health Congress

Last month, the 2025 American Diabetes Association (ADA) guidelines were introduced, providing updates for diagnosing and managing diabetes and prediabetes. These new guidelines offer actionable, evidence-based recommendations to improve care delivery. 1. ADA Updates: Continuous Glucose Monitoring (CGM) for Type 2 Diabetes on Glucose-Lowering Agents The ADA now recommends considering CGM for adults with type 2 diabetes who are using glucose-lowering agents other than insulin.

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Biosimilars Month in Review: December 2024

HCPLive

The biosimilars month in review highlights a newly approved ustekinumab biosimilar and a look into the field in 2024.

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Inside the expansion plans of Broward Health's 1st cardiology chief

Becker's Hospital Review - Cardiology

Jose Baez-Escudero, MD, in November stepped into his role as the first systemwide chief of cardiology at Fort Lauderdale, Fla.-based Broward Health, where he also now serves as chief of cardiac electrophysiology.

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FDA Grants Orphan Drug Designation to CNP-104 for Primary Biliary Cholangitis

HCPLive

The designation follows positive topline data from the phase 2a trial of CNP-104 in PBC, which were presented at AASLDs The Liver Meeting

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The efficacy and safety of indobufen in patients with ischemic cardiovascular or cerebrovascular diseases: systematic review and meta-analysis

Frontiers in Cardiovascular Medicine

ObjectiveThis meta-analysis aims to evaluate the safety and efficacy of indobufen in the treatment of cardiovascular diseases, cerebrovascular diseases, and thromboembolic disorders. The primary focus is on the incidence of major adverse cardiovascular events (MACE), thrombosis, bleeding events, and adverse reactions. The results are intended to provide a reference for the clinical application of indobufen and suggest directions for further large-scale, multi-center, prospective studies.MethodsT

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Global Atopic Dermatitis Among Children Projected to Rise Over 50 Years

HCPLive

This analysis using worldwide data from GBD 2021 indicates that the global burden of eczema in children has gradually risen and has been projected to continue increasing.

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DEPDC1B, CDCA2, APOBEC3B, and TYMS are potential hub genes and therapeutic targets for diagnosing dialysis patients with heart failure

Frontiers in Cardiovascular Medicine

IntroductionHeart failure (HF) has a very high prevalence in patients with maintenance hemodialysis (MHD). However, there is still a lack of effective and reliable HF diagnostic markers and therapeutic targets for patients with MHD.MethodsIn this study, we analyzed transcriptome profiles of 30 patients with MHD by high-throughput sequencing. Firstly, the differential genes between HF group and control group of patients with MHD were screened.

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LB-102 Shows Promise in Reducing Acute Schizophrenia Symptoms: New Phase 2 Data

HCPLive

Phase 2 data demonstrates the effectiveness of LB-102, developed with the potential to be the first-in-class benzamide antipsychotic, for adults with acute schizophrenia.

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Impact of high hemoglobin levels on carotid artery intima–media thickness and its predictive value for hypertension in high-altitude areas: a real-world study

Frontiers in Cardiovascular Medicine

Background and purposeThe hemoglobin levels in the peripheral blood of individuals living at high altitudes are significantly higher than normal levels. These levels are closely associated with atherosclerosis and cardiovascular events. This study aimed to investigate the correlation between hemoglobin levels in the peripheral blood and hypertension in high-altitude regions, providing a basis for preventing and treating primary hypertension in these regions.Materials and methodsFrom May 2020 to

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Pediatric Lipid Treatment Recommendations

HCPLive

Panelists discuss how statin therapy can be initiated in children with familial hypercholesterolemia as early as 8 to 10 years old, following careful evaluation and lifestyle interventions.

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Mineralys Therapeutics Announces Phase 2 Clinical Trial of Lorundrostat

DAIC

tim.hodson Wed, 01/08/2025 - 14:11 Jan. 8, 2025 Mineralys Therapeutics, Inc., a clinical-stage biopharmaceutical company focused on developing medicines to target hypertension, chronic kidney disease (CKD) and other diseases, hasannounced that the U.S. Food and Drug Administration (FDA) has cleared the companys Investigational New Drug (IND) Application for a Phase 2 clinical trial to evaluate the effect of lorundrostat in the treatment of subjects with moderate-to-severe obstructive sleep apne

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Increased Risk of Surgical Aortic Valve Replacement After Prior Transcatheter vs. Surgical Aortic Valve Replacement with Concomitant Valve Disease

Society of Thoracic Surgeons - Congenital

News Increased Risk of Surgical Aortic Valve Replacement After Prior Transcatheter vs.

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APOC3 Inhibitors

HCPLive

Panelists discuss important novel therapies emerging for familial chylomicronemia syndrome (FCS), focusing on APOC3 inhibitors, including small interfering RNA (siRNA) and antisense oligonucleotides (ASO), and their potential to address the underlying lipid metabolism dysfunction in patients with FCS.

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American College of Cardiology to honor 21 industry leaders

Becker's Hospital Review - Cardiology

"Discover the 21 industry leaders being honored by the American College of Cardiology for their contributions to global cardiovascular care and outcomes.

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Navigating Lifestyle and Pharmacotherapy Interventions in Dyslipidemia Management

HCPLive

Panelists discuss how lifestyle interventions, including diet, physical activity, and smoking cessation, complement pharmacotherapy in the management of dyslipidemia, and explore unmet needs in cardiovascular risk reduction, highlighting the role of emerging therapies such as bempedoic acid, inclisiran, and gene editing technologies.

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