Mon.Feb 03, 2025

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Structural characterization of human monoclonal antibodies targeting uncommon antigenic sites on spike glycoprotein of SARS-CoV

Journal of Clinical Investigation - Cardiology

The function of the spike protein N terminal domain (NTD) in coronavirus (CoV) infections is poorly understood. However, some rare antibodies that target the SARS-CoV-2 NTD potently neutralize the virus. This finding suggests the NTD may contribute, in part, to protective immunity. Pansarbecovirus antibodies are desirable for broad protection, but the NTD region of SARS-CoV and SARS-CoV-2 exhibit a high level of sequence divergence; therefore, cross-reactive NTD-specific antibodies are unexpecte

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Palliative Care for Dementia Cuts Emergency Department Visits, with Greg A. Sachs, MD

HCPLive

HCPLive spoke with Sachs about his study on palliative care for dementia, which reduced ED visits but didnt significantly improve neuropsychiatric symptoms.

Dementia 119
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Heart Protection With SGLT2, GLP-1 Drugs for Diabetes Mediated by Age

Med Page Today

(MedPage Today) -- The age of type 2 diabetes patients may alter the level of cardioprotection from two newer classes of anti-diabetic agents, a network meta-analysis suggested. The relative reduction in major adverse cardiovascular events (MACE.

Diabetes 105
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FDA Clears First Xenotransplant Trial for Gene-Edited Kidneys

HCPLive

United Therapeutics investigational UKidney is derived from a 10 gene-edited source pig and will be tested in a clinical study of ESRD patients.

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Metalloproteinase inhibitors regulate biliary progenitor cells through sDLK1 in organoid models of liver injury

Journal of Clinical Investigation - Cardiology

Understanding cell fate regulation in the liver is necessary to advance cell therapies for hepatic disease. Liver progenitor cells (LPCs) contribute to tissue regeneration after severe hepatic injury, yet signals instructing progenitor cell dynamics and fate are largely unknown. Tissue inhibitor of metalloproteinases 1 (TIMP1) and TIMP3 control the sheddases ADAM10 and ADAM17, key for NOTCH activation.

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Rheumatology Month in Review: January 2025

HCPLive

The rheumatology month in review emphasizes new research in gout, fibromyalgia, and psoriatic arthritis.

Research 109
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Cerebral Blood Flow in Orthostatic Intolerance

Journal of the American Heart Association

Journal of the American Heart Association, Ahead of Print. Cerebral blood flow (CBF) is vital for delivering oxygen and nutrients to the brain. Many forms of orthostatic intolerance (OI) involve impaired regulation of CBF in the upright posture, which results in disabling symptoms that decrease quality of life. Because CBF is not easy to measure, rises in heart rate or drops in blood pressure are used as proxies for abnormal CBF.

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Vascular smooth muscle cell PRDM16 regulates circadian variation in blood pressure

Journal of Clinical Investigation - Cardiology

Disruptions of blood pressure (BP) circadian variation are closely associated with an increased risk of cardiovascular disease. Thus, gaining insights into the molecular mechanisms of BP circadian variation is essential for comprehending BP regulation. Human genetic analyses suggest that PR domaincontaining protein 16 (PRDM16), a transcription factor highly expressed in vascular smooth muscle cells (VSMCs), is significantly associated with BP-related traits.

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Tocilizumab Biosimilar Approved for Rheumatological Diseases, COVID-19

HCPLive

Tocilizumab-anoh will be available in both intravenous and subcutaneous formulations.

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A protein at the heart of heart disease

Science Daily - Heart Disease

Low-density lipoproteins (LDL) -- commonly known as bad cholesterol -- have long been on scientists' radar as a major contributor to heart disease. But these microscopic troublemakers have hidden their inner workings behind a maze of complexity. That is, until now. Researchers have now revealed the specific shape and structure of one of the body's most important yet complicated proteins: ApoB100.

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Skin of Color Savvy: Pigmentary Disorders in Skin of Color, with Nada Elbuluk, MD, and Michelle Rodrigues, MBBS

HCPLive

In this episode, Nada Elbuluk, MD, and Michelle Rodrigues, MBBS, discuss diagnosis and management of pigmentary disorders in skin of color.

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NEDD4L mediates intestinal epithelial cell ferroptosis to restrict inflammatory bowel diseases and colorectal tumorigenesis

Journal of Clinical Investigation - Cardiology

Various factors play key roles in maintaining intestine homeostasis. Disruption of the balance may lead to inflammatory bowel diseases and even colorectal cancer (CRC). Loss or gain of function of many key proteins can result in dysregulated intestinal homeostasis. Our research demonstrated that neural precursor cells expressed developmentally downregulated 4like protein (NEDD4L, or NEDD4-2), a type of HECT family E3 ubiquitin ligase, played an important role in maintaining intestinal homeostasi

Cancer 64
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Development and Evaluation of a Deep Learning–Based Pulmonary Hypertension Screening Algorithm Using a Digital Stethoscope

Journal of the American Heart Association

Journal of the American Heart Association, Ahead of Print. BackgroundDespite the poor outcomes related to the presence of pulmonary hypertension, it often goes undiagnosed in part because of low suspicion and screening tools not being easily accessible such as echocardiography. A new readily available screening tool to identify elevated pulmonary artery systolic pressures is needed to help with the prognosis and timely treatment of underlying causes such as heart failure or pulmonary vascular re

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Mothers of twins face a higher risk of heart disease in the year after birth

Science Daily - Heart Disease

The risk of being admitted to the hospital with heart disease is twice as high the year after birth for mothers of twins compared to singleton births, according to new research. The risk is even higher in mothers of twins who had a high blood pressure condition during pregnancy.

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ACC Celebrates Heart Month 2025

American College of Cardiology

Join the ACC in celebrating Heart Month! Start off the month by reading the February issue of Cardiology magazine, including articles on health equity, life expectancy disparities in the U.S., polypharmacy for older adults and more.

Article 65
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IL-6 Cytokine Useful for Monitoring of Severe Epidermolysis Bullosa

HCPLive

Targeted anti-inflammatory treatment may be reasonable for addressing the causes ofsystemic inflammation in those with severe junctional and dystrophic epidermolysis bullosa.

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4 ways heart centers are improving patient outcomes

Becker's Hospital Review - Cardiology

Discover how heart centers across the country are improving patient outcomes and reducing mortality rates through innovative approaches and advanced therapies.

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Beclin 1 prevents ISG15-mediated cytokine storms to secure fetal hematopoiesis and survival

Journal of Clinical Investigation - Cardiology

Proper control of inflammatory responses is essential for embryonic development, but the underlying mechanism is poorly understood. Here, we show that under physiological conditions, inactivation of ISG15, an inflammation amplifier, is associated with the interaction of Beclin 1 (Becn1), via its evolutionarily conserved domain, with STAT3 in the major fetal hematopoietic organ of mice.

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Road to Boston Training Log | Week 1

Physiologically Speaking

This week marked week 1 of my 12-week marathon training block which I’m referring to as the “Road to Boston.” Each week I’ll share details about my training, some insights, and other musings as I train for the 2025 Boston Marathon. Thanks for following along! You can also find my training on Strava. Physiologically Speaking is a reader-supported publication.

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GH001 Achieves Significant Depression Symptom Reduction in Phase 2b Trial

HCPLive

GH Research's phase 2b trial found GH001, an inhalable 5-MeO-DMT treatment, led to a -15.5 MADRS score reduction by day 8 in patients with treatment-resistant depression.

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Roche's Lp(a) Gen.2 Molarity Assay Receives FDA Clearance

DAIC

tim.hodson Mon, 02/03/2025 - 12:30 January 29, 2025 Roche announced today that the Tina-quant Lipoprotein (a) Gen.2 Molarity assay has received 510(k) clearance from the United States Food and Drug Administration (FDA). This will be the first 510(k) cleared test of its kind available in the U.S. measuring lipoprotein (a), or Lp(a), in nanomoles per liter (nmol/L).

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Cardiology Month in Review: January 2025

HCPLive

The January 2025 cardiology month in review highlights new NDA acceptances, clearance of the first Lp(a) test in molar units, and national trends in preventive aspirin use.

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ACC CardiaCast: Conversations with Critical Care Cardiologists: Advanced Education and Training in CCC

American College of Cardiology

Join us as we explore the future of CCC training, the role of medical societies, and strategies for ensuring consistency and excellence in educationboth within CCC and across the broader field of cardiology.

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Cathelicidin antimicrobial peptide expression in neutrophils and neurons antagonistically modulates neuroinflammation

Journal of Clinical Investigation - Cardiology

Multiple sclerosis (MS) is an autoimmune disease that affects the CNS, the pathophysiology of which remains unclear and for which there is no definitive cure. Antimicrobial peptides (AMPs) are immunomodulatory molecules expressed in various tissues, including the CNS. Here, we investigated whether the cathelicidin-related AMP (CRAMP) modulated the development of experimental autoimmune encephalomyelitis (EAE), a mouse model of MS.

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Case Report: Two-month-old infant with PHACE syndrome: facial hemangioma and severe complex coarctation of the aorta

Frontiers in Cardiovascular Medicine

BackgroundPHACE syndrome is an uncommon disorder, marked by large segmental hemangiomas on the face and various developmental anomalies. Significant advancements have been made in its diagnosis, imaging, and understanding of complications since 1996.Case SummaryWe describe the first diagnosis case of PHACE syndrome in a one-month and 19-day-old infant who presented with a large facial hemangioma and coarctation of the aorta originating from the left common carotid artery, along with an aberrant

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A deafness-blindness syndrome results from ATF6-based disruption of the unfolded protein response

Journal of Clinical Investigation - Cardiology

Sensorineural hearing loss (SNHL) is the most prevalent form of permanent hearing impairment, arising from factors such as aging, exposure to loud noise, disease, ototoxic medications, and genetic mutations. Despite extensive research, effective treatments or cures for SNHL remain elusive. In this issue of the JCI, Lee et al. reveal a link between mutations in ATF6 and SNHL in patients with achromatopsia.

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PURE: Secondary Prevention Medications For CVD Underused Globally

American College of Cardiology

Secondary prevention medications for cardiovascular diseases are underused globally and additional strategies to increase their use are needed to improve management and reduce premature mortality rates, according to results from the PURE study.

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Bulk Ordering Boosts Lipid Screening Uptake Versus Usual Care

HCPLive

Lipid screening after bulk orders and outreach letters increased significantly at 3 months, but supplemental text messaging had no further impact.

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University Hospitals names cardiac surgery chief

Becker's Hospital Review - Cardiology

"University Hospitals names Dr. Yasir Abu-Omar as Chief of Cardiac Surgery at Harrington Heart & Vascular Institute.

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Postischemic inactivation of HIF prolyl hydroxylases in endothelium promotes maladaptive kidney repair by inducing glycolysis

Journal of Clinical Investigation - Cardiology

Ischemic acute kidney injury (AKI) is common in hospitalized patients and increases the risk for chronic kidney disease (CKD). Impaired endothelial cell (EC) functions are thought to contribute in AKI to CKD transition, but the underlying mechanisms remain unclear. Here, we identify a critical role for endothelial oxygen sensing prolyl hydroxylase domain (PHD) enzymes 13 in regulating postischemic kidney repair.

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Cardiology groups launch resource for underdiagnosed condition

Becker's Hospital Review - Cardiology

"Learn about peripheral artery disease and its impact on 10 million Americans.

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Shorter Telomere Length Linked to Increased Risk of Stroke, Dementia, Depression

HCPLive

A study indicated that telomere length may not directly cause age-related brain diseases, but healthier lifestyles could counteract the harmful effects of shorter telomeres.

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Hackensack Meridian hospital adopts AI for cardiac care

Becker's Hospital Review - Cardiology

Montclair, N.J.-based Hackensack Meridian Mountainside Medical Center has adopted two AI platforms designed for the diagnosis and treatment of coronary artery disease.

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Study Highlights Success of Upadacitinib for Atopic Dermatitis in Various Clinical Phenotypes

HCPLive

This study highlights upadacitinibs efficacy across clinical phenotypes for those with atopic dermatitis, noting any differences in response rates among patients.

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Clinical Practice Algorithm For the Follow-Up of Repaired and Unrepaired Atrioventricular Septal Defects

American College of Cardiology

Approximately 2,700 children (~5/10,000 live births) are born annually with atrioventricular septal defect (AVSD). AVSD represents a spectrum of congenital heart lesions that result from abnormal embryologic development of the endocardial cushions in the primitive atrioventricular (AV) canal.

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Summary and Closing Remarks

HCPLive

Panelists summarize the key points discussed regarding the evolving landscape of IgA nephropathy treatments, highlighting the importance of addressing unmet needs, the significance of reducing proteinuria, and the role of emerging therapies in modifying disease progression, ultimately emphasizing the necessity for personalized treatment approaches and effective communication with patients to improve clinical outcomes.

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Cardiac Gene Therapy With Phosphodiesterase 2A Limits Remodeling and Arrhythmias in Mouse Models of Heart Failure

Journal of the American Heart Association

Journal of the American Heart Association, Ahead of Print. BackgroundPDE2 (phosphodiesterase 2) is upregulated in human heart failure. Cardiac PDE2transgenic mice are protected against contractile dysfunction and arrhythmias in heart failure but whether an acute elevation of PDE2 could be of therapeutic value remains elusive. This hypothesis was tested using cardiac PDE2 gene transfer in preclinical models of heart failure.Methods and ResultsC57BL/6 male mice were injected with serotype 9 adenoa