Wed.Sep 18, 2024

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Metals in the body from pollutants associated with progression of harmful plaque buildup in the arteries

Medical Xpress - Cardiology

Metal exposure from environmental pollution is associated with increased buildup of calcium in the coronary arteries at a level that is comparable to traditional risk factors like smoking and diabetes, according to a study by Columbia University Mailman School of Public Health.

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Metal Exposure Also Linked to More Coronary Artery Calcium

Med Page Today

(MedPage Today) -- Exposure to metals, essential or not, was associated with the progression of subclinical atherosclerosis, according to longitudinal data from a geographically diverse cohort. Study participants with the highest urinary metal.

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A transparent AI approach helps provide a more tailored cardiovascular risk assessment

Medical Xpress - Cardiology

Risk calculators are used to evaluate disease risk for millions of patients, making their accuracy crucial. But when national models are adapted for local populations, they often deteriorate, losing accuracy and interpretability.

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New Report Estimates Potential Demand of Psilocybin-Assisted Therapy for MDD

HCPLive

A report shows only 24%, 56%, and 62% of patients meet the criteria PSIL-AT for depression according to low-bound, mid-range, and upper-bound estimates, respectively.

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Happy with your life? Research links contentment with fewer heart attacks and strokes

Medical Xpress - Cardiology

People who are content with their lives or feel a sense of well-being may be less likely to develop heart disease and/or stroke compared to those with a lower sense of well-being, according to a new analysis published today (Sept. 18) in the Journal of the American Heart Association.

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ASN Releases New Guidance on Obesity Management in Kidney Disease

HCPLive

The new guidance reviews existing tools for weight management and provides recommendations for their use in clinical practice in patients with obesity and kidney disease.

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Metal exposure can increase cardiovascular disease risk

Science Daily - Heart Disease

Metal exposure from environmental pollution is associated with increased calcium buildup in the coronary arteries at a level comparable to traditional risk factors, according to a new study. The findings support that metals in the body are associated with the progression of plaque buildup in the arteries and potentially provide a new strategy for managing and preventing atherosclerosis.

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FDA Clears Eversense 365, Marking First 1-Year CGM Option in Diabetes

HCPLive

The FDA has approved the Eversense 365, the world’s first 1-year continuous glucose monitor, with US availability expected in late 2024.

Diabetes 105
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Researchers develop nanoparticle technology for targeted diagnosis and treatment of atherosclerosis

Science Daily - Heart Disease

A team developed a nanoparticle technology that offers an effective solution to diagnose and treat atherosclerosis, in a non-invasive manner. Atherosclerosis is the build-up of plaque in the arteries which causes their narrowing and is a primary cause of ischemic heart disease (IHD) and ischemic stroke (IS), major contributors to deaths caused by cardiovascular diseases globally.

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Polluted air, disturbed hearts: Study ties air quality to cardiac health

Medical Xpress - Cardiology

Arrhythmias, a group of disorders that disrupt the normal rhythm of the heart, can lead to serious health complications such as heart failure, stroke, and sudden death. The global prevalence of arrhythmias, particularly atrial fibrillation, is on the rise, contributing to substantial health and economic burdens.

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Exercise Alleviates Cardiovascular Diseases by Improving Mitochondrial Homeostasis

Journal of the American Heart Association

Journal of the American Heart Association, Ahead of Print. Engaging in regular exercise and physical activity contributes to delaying the onset of cardiovascular diseases (CVDs). However, the physiological mechanisms underlying the benefits of regular exercise or physical activity in CVDs remain unclear. The disruption of mitochondrial homeostasis is implicated in the pathological process of CVDs.

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Analysis suggests air pollution, high temperatures and metabolic risk factors drive global increases in stroke

Medical Xpress - Cardiology

Although stroke is highly preventable and treatable, there has been a rapid rise in the global stroke burden between 1990 and 2021, due to both population growth and the rise of aging populations worldwide, as well as a substantial increase in people's exposure to environmental and behavioral risk factors.

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Syncope while on a treadmill

Dr. Smith's ECG Blog

A 60-something ow healthy male had syncope while on treadmill. 911 was called and the patient was found by medics to be diaphoretic and hypotensive. This strip was obtained: Apparent Wide Complex Tachycardia at a rate of 280 What do you think? What do you want to do? Appropriately, the medics electrically cardioverted immediately. They did not feel they had time to sedate.

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Researchers use machine learning to improve cardiovascular risk assessment

Science Daily - Heart Disease

Researchers used advanced machine learning to increase the accuracy of a national cardiovascular risk calculator while preserving its interpretability and original risk associations.

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Coffee and Heart, Metabolic Risks; What Drives Doctors Away; Ozempic for $100?

Med Page Today

(MedPage Today) -- Note that some links may require registration or subscription. Habitual moderate coffee consumption -- 200-300 mg of caffeine/day -- was tied to a lower risk of cardiometabolic multimorbidity, a U.K. Biobank analysis found.

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FDA Approves Benralizumab for Eosinophilic Granulomatosis with Polyangiitis

HCPLive

Announced on September 18, 2024, the approval of benralizumab for adults with EGPA, which is based on the MANDARA trial, marks the second FDA approval for EGPA.

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Clinical trial demonstrates success in treating rare blood disorder

Medical Xpress - Cardiology

A clinical trial has demonstrated that the cancer drug pomalidomide is safe and effective in treating hereditary hemorrhagic telangiectasia (HHT), a rare bleeding disorder that impacts more than one in 5,000 people worldwide.

Cancer 66
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Questioning PCI’s Left Ventricular Dysfunction Effect

CardiacWire

New analysis of the REVIVED-BCIS2 trial adds more evidence that PCI has limited impact in patients with left ventricular dysfunction, even when you include quality of life and overall health status. The secondary analysis of the REVIVED-BCIS2 trial examined outcomes from 700 patients with severe ischemic left ventricular systolic dysfunction (median age: 70yrs; mean LVEF: 27) who were randomized to receive PCI and optimal medical therapy or only optimal medical therapy.

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Caffeine, coffee linked to lower cardiometabolic multimorbidity risk

Medical Xpress - Cardiology

Habitual coffee or caffeine intake is associated with a lower risk for new-onset cardiometabolic multimorbidity (CM), according to a study published online Sept. 17 in the Journal of Clinical Endocrinology & Metabolism.

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What Causes Respiratory Problems in Osteogenesis Imperfecta?

HCPLive

Roy Morello, MD, discusses his team's research into the causes of poor pulmonary function among patients with osteogenesis imperfecta—better known as "brittle bone disease.

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Aortic Valve ReplAcemenT versus Conservative Treatment in Asymptomatic SeveRe Aortic Stenosis

American College of Cardiology

The goal of the AVATAR trial was to evaluate aortic valve replacement (AVR) compared with conservative therapy among patients with asymptomatic severe aortic stenosis.

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Adding Brief CBT to Inpatient’s Usual Treatment Reduces Suicide Reattempts

HCPLive

Inpatients receiving brief cognitive behavioral therapy had a 60% reduced likelihood of suicide attempts and a 71% reduced rate of psychiatric readmissions post-discharge.

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Finerenone improves outcomes in HFmrEF and HFpEF

Nature Reviews - Cardiology

Nature Reviews Cardiology, Published online: 19 September 2024; doi:10.1038/s41569-024-01087-x The non-steroidal mineralocorticoid receptor antagonist finerenone reduces the risk of adverse outcomes in patients with heart failure with mildly reduced ejection fraction or with preserved ejection fraction, according to findings presented at the ESC Congress 2024.

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Using Microbiomes to Diagnose Ventilator-Associated Pneumonia

HCPLive

Georgios Kitsios, MD, PhD, discusses his team's interim results an analysis that is providing insights into the microbiome dynamics of critically ill patients with VAP.

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TEER is non-inferior to surgery in patients with secondary mitral regurgitation

Nature Reviews - Cardiology

Nature Reviews Cardiology, Published online: 19 September 2024; doi:10.1038/s41569-024-01089-9 In patients with heart failure and secondary mitral valve regurgitation, transcatheter edge-to-edge repair is non-inferior to mitral valve surgery with respect to a composite of death, hospitalization for heart failure, reintervention, implantation of an assist device or stroke at 1 year after the procedure, according to findings from the MATTERHORN trial.

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Ustekinumab Reduces Uveitis Risk in Patients with Psoriasis

HCPLive

The IL-23 inhibitor lowered the risk of uveitis more than TNF-α inhibitors in patients with moderate to severe psoriasis.

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Iron metabolism indexes as predictors of the incidence of cardiac surgery-associated acute kidney surgery

Journal of Cardiothoracic Surgery

Acute kidney injury (AKI) is a major complication following cardiac surgery. We explored the clinical utility of iron metabolism indexes for identification of patients at risk for AKI after cardiac surgery.

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What Do Patients Need to Learn About their Hypersensitivity Pneumonitis?

HCPLive

Kerri Aronson, MD, MS, describes her team's research efforts to create educational resources that address the profound lack of patient knowledge around HP.

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Uniportal left middle lobectomy in a patient with situs inversus totalis: a case report

Journal of Cardiothoracic Surgery

Situs inversus totalis (SIT), a rare recessive autosomal disease, involves the complete transposition of the thoracic and abdominal viscera in the left-right axis. Patients with SIT combined with lung cancer a.

Cancer 52
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Updates to the Treatment of Rosacea, with Hilary Baldwin, MD

HCPLive

In her Maui Derm NP+PA Fall conference presentation, Baldwin highlighted the latest information on approaches to treating rosacea.

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Recovery rate from conduction disorders in patients with permanent pacemaker implantation after transcatheter aortic valve implantation

Open Heart

Backgrounds Permanent pacemaker implantation (PPMI) is one of the greatest disadvantages of transcatheter aortic valve implantation (TAVI). To seek the predictors and clinical impacts of PPMI and investigate the recovery rate from conduction disorders. Methods We retrospectively analysed data from 745 consecutive patients who underwent TAVI for severe aortic stenosis from November 2013 to July 2022.

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Use of Existing Treatment and Ongoing Research in Treatment of Fibromyalgia

HCPLive

A key opinion leader discusses off-label treatments for fibromyalgia symptom management and promising ongoing studies, as well as mobile applications that can aid in monitoring and managing fibromyalgia symptoms.

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Appropriate use of wearable defibrillators with multiparametric evaluation to avoid unnecessary defibrillator implantation

Open Heart

Introduction Wearable cardioverter-defibrillators (WCD) have emerged as a valuable tool in the management of patients at risk for life-threatening arrhythmias. These devices offer a non-invasive and temporary solution, providing continuous monitoring and the potential for prompt defibrillation when needed. In this study, we explore the use of WCD and evaluate arrhythmic events through comprehensive monitoring.

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Study identifies link between congenital heart disease prevalence and high-altitude environments

Medical Xpress - Cardiology

The global prevalence of congenital heart disease is higher among women who live at high altitudes, according to a new study presented at ACC Latin America 2024 in Punta Cana, Dominican Republic. However, congenital heart disease in these regions is underestimated and underdiagnosed because of poor access to health care and health systems that lack essential tools.

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Developing Risk Assessment Tools for Viruses in School

HCPLive

Amanda Wilson, PhD, details how her team is developing risk assessment models to evaluate viral infection intervention in schools.

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Complete Revascularization in Older Patients With STEMI

American College of Cardiology

What are long-term clinical benefits of complete versus culprit-only revascularization among ST-segment elevation myocardial infarction (STEMI) patients aged ≥75 years?

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Most Exciting New Therapies in Atopic Dermatitis, with Matthew Zirwas, MD

HCPLive

Zirwas described several highlights from his presentation on updates in managing atopic dermatitis, describing examples such as lebrikizumab and nemolizumab.

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