Tue.Dec 03, 2024

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Cognitive Performance Falls as Metal Exposure Rises

Med Page Today

(MedPage Today) -- Traces of nine essential metals and non-essential metals in urine were linked with lower cognitive performance and the risk of future dementia, a large prospective study showed. The study assessed concentrations of the essential.

Dementia 138
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This Year in Medicine 2024: Stories that Defined Healthcare

HCPLive

An overview and landing page for future installments from HCPLive's 8th annual This Year in Medicine Series.

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Tiny, daily bursts of vigorous incidental physical activity could almost halve cardiovascular risk in middle-aged women

Science Daily - Heart Disease

An average of four minutes of incidental vigorous physical activity a day could almost halve the risk of major cardiovascular events, such as heart attacks, for middle-aged women who do not engage in structured exercise, according to new research.

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Daily Chores May Provide Cardiovascular Protection in Women Who Don't Exercise

Med Page Today

(MedPage Today) -- Short, intense bouts of physical activity during daily life were associated with a lower risk of major adverse cardiovascular events (MACE) in non-exercising women, according to an observational study. A median 3.4 minutes of.

Exercise 115
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What can you find with continuous ST monitoring in the ED?

Dr. Smith's ECG Blog

This was written by one of our fine residents, who will soon be an EMS fellow: Michael Perlmutter Case A mid-50s male came to the ED with a burning sensation that was acutely worse while at home. He had recently returned from overseas travel where these symptoms had been intermittently bothersome over the preceding weeks and had been attributed to heartburn.

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Small amounts of incidental vigorous physical exertion may almost halve major cardiovascular events risk in women

Medical Xpress - Cardiology

Short bursts of incidental vigorous physical exertion, lasting less than a minute each, may almost halve the risk of a major cardiovascular event, such as heart attack or heart failure among women who don't exercise regularly, finds research published online in the British Journal of Sports Medicine.

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ECG Cases 52 – The Art of Occlusion MI, part 1: Mirror Image

ECG Cases

In this month's ECG Cases Jesse McLaren takes us through 6 cases highlighting important mirror concepts in ECG interpretation including: which leads are reciprocal to each other, how to identify which is the main ST/T change and which is the mirror, reciprocal changes highlighting subtle inferior, lateral and posterior OMI, ST elevation in aVR as a mirror to widespread ST depression and more.

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Impact of Smokeless Oral Nicotine Products on Cardiovascular Disease: Implications for Policy, Prevention, and Treatment: A Policy Statement From the American Heart Association

Circulation

Circulation, Ahead of Print. Smokeless oral nicotine products are addictive, and their use has potential adverse effects on some but not all biomarkers of cardiovascular risk. The use of some types of these products, for instance, is associated with an increased mortality risk in those with ischemic heart or cerebrovascular disease. Similarly, smokeless tobacco has the potential to increase the risk of oral cancer, but the risks depend on the chemical composition of the product.

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Trials and tribulations of cell therapy for heart failure, an update on ongoing trials

Medical Xpress - Cardiology

Pathways to new treatments for heart failure take timeas long as four decades for two now accepted therapies. So, new attempts to repair scar tissue in infarcted hearts using cells or cell products need more time to develop clinical therapies that can reduce risk of death from heart failure after a heart attack.

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Esperion Presents New Data from CLEAR Outcomes Trial Highlighting Value of NEXLETOL

DAIC

tim.hodson Tue, 12/03/2024 - 16:52 Nov. 18, 2024 — In November, Esperion presented an analysis from the CLEAR Outcomes study focused on patients with Peripheral Artery Disease (PAD) who were unable or unwilling to take statin medications. These data were presented at the 2024 American Heart Association Scientific Sessions, in Chicago, IL. Additionally, two exploratory analyses from the CLEAR Outcomes trial and a real-world analysis of bempedoic acid usage were presented at the conference.

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EM Quick Hits 61 TEE in Cardiac Arrest, Nebulized Ketamine, Cellulitis Update, SQ Insulin for DKA, Medicolegal DDx Documentation Tips

ECG Cases

On this month's EM Quick Hits podcast: Ross Prager on TEE in cardiac arrest, Justin Morgenstern on nebulized ketamine for analgesia in the ED, Hans Rosenberg & Krishin Yadav on standardizing cellulitis management, Mathew McArther on latest studies on subcutaneous insulin protocols in DKA, Jennifer C. Tang on documenting differential diagnoses medicolegal tips.

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Traditional Chinese medicine for cardiovascular disease: efficacy and safety

Frontiers in Cardiovascular Medicine

In China and other Asian nations, traditional medicine has long been utilized in the treatment of cardiovascular diseases (CVD). While Chinese authorities have incorporated traditional Chinese medicine (TCM) treatment experiences as a supplementary guide for CVD, its international recognition remains limited due to a scarcity of high-quality and reliable randomized controlled trials (RCTs) evidence.

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Endoscopy in the Age of GLP-1 RAs: 2024 Sees New Risk-Based Perioperative Guidance

HCPLive

Previous ASA guidance recommended holding GLP-1 RAs in the perioperative period, but new 2024 multisociety guidance suggests a risk-based approach.

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Case Report: A novel method of needle-free transseptal puncture

Frontiers in Cardiovascular Medicine

BackgroundIn the era of fluoroless catheter ablation (CA), achieving a successful transseptal puncture (TSP) presents a significant challenge. We introduce a novel technique for zero-fluoroscopy and cost-effective needle-free TSP.Case summaryWe describe two cases where a GMS-1 guidewire (0.025 inch, pigtail configuration; Toray Medical Co., Ltd., Japan) was utilized for TSP.

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Allergy Month in Review | November 2024

HCPLive

In this iteration of the Month in Review series, a list of highlighted stories in the allergy and immunology space covered in the month of November is provided.

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The "Why" of Shared Decision-Making With Athletes: Highlights From the "Courtside with the Chair" Podcast

American College of Cardiology

Because of recent incidents of sudden cardiac arrest (SCA) among high-profile athletes, including Damar Hamlin and Bronny James, there has been greater scrutiny regarding the medical evaluation process for athletes.

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Intra-Cellular Therapies Submits sNDA to FDA for Lumateperone as an MDD Adjunctive Therapy

HCPLive

Intra-Cellular Therapies announced they submitted a supplemental New Drug Application to the FDA for lumateperone (CAPLYTA) as an adjunctive therapy to antidepressants for MDD.

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Correlation between admission blood glucose, fibrinogen, and slow blood flow during primary PCI for acute ST segment elevation myocardial infarction

Frontiers in Cardiovascular Medicine

BackgroudCoronary slow flow (CSF) is a common phenomenon of coronary microcirculation dysfunction, and is closely related to elevated blood glucose and fibrinogen (FIB) levels. However, whether immediate blood glucose and FIB levels affect coronary blood flow during primary percutaneous coronary intervention (PCI) remains unclear.ObjectiveTo explore the correlation between admission blood glucose (ABG), fibrinogen (FIB) and slow blood flow during primary PCI for acute ST segment elevation myocar

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Revascularization in Frail Patients With ACS

American College of Cardiology

Is revascularization beneficial for patients presenting with acute coronary syndrome (ACS) and at higher risk for frailty?

Article 56
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Deadline Extended: Special Collection on Artificial Intelligence in Cardiovascular Health

International Journal of Cardiovascular Sciences

We would like to inform you that the deadline for submitting articles for the special collection on Artificial Intelligence in Cardiovascular Health has been extended to March 1, 2024. This special collection aims to explore advancements, applications, and challenges of artificial intelligence in the context of cardiovascular health, promoting the dissemination of knowledge and scientific innovations in the field.

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Elevated whole blood viscosity is associated with an impaired insulin-stimulated myocardial glucose metabolism

Cardiovascular Diabetology

Increased whole blood viscosity (WBV) was associated with impaired peripheral glucose metabolism, type 2 diabetes, and cardiovascular disease (CVD). Impaired myocardial glucose metabolism is a risk factor for.

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Application of pedicle combined muscle flaps in treatment of chronic empyema with huge irregular abscess cavity after pulmonary surgery: a case report and literature review

Journal of Cardiothoracic Surgery

Chronic empyema is usually considered to be very challenging in clinical management and has a high mortality rate. On this basis, if combined with bronchopleural fistula (BPF) and huge irregular abscess cavity.

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ApoC-III proteoforms are associated with better lipid, inflammatory, and glucose profiles independent of total apoC-III

Cardiovascular Diabetology

Apolipoprotein (apo) C-III is involved in several processes that increase triglyceride levels, inflammation, and insulin resistance. Four of its proteoforms have been the focus of several studies and have show.

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Extranodal Rosai-Dorfman disease masquerading as intrathoracic invasive malignancy with ankylosing spondylitis: a case report

Journal of Cardiothoracic Surgery

Rosai-Dorfman Disease (RDD), also known as sinus histiocytosis with massive lymphadenopathy, is an uncommon histiocytic disorder. It may be associated with autoimmune diseases, but there are few reports of con.

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SGLT2 inhibitor downregulates ANGPTL4 to mitigate pathological aging of cardiomyocytes induced by type 2 diabetes

Cardiovascular Diabetology

Senescence is recognized as a principal risk factor for cardiovascular diseases, with a significant association between the senescence of cardiomyocytes and inferior cardiac function. Furthermore, type 2 diabe.

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Denosumab Biosimilar Demonstrates Equivalent Efficacy, Safety in Phase 3 Trial

HCPLive

CT-P41 had similar rates of bone mineral density increases and adverse events in data presented at the ACR 2024 Convergence.

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Timelier U.S. Guidelines; Spouse's Personality & CVD; 'Hostile' Cardiologists Out

Med Page Today

(MedPage Today) -- To facilitate more timely guideline updates, the American College of Cardiology and the American Heart Association have committed to annual guideline "maintenance" and single recommendation updating. (Journal of the American.

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Anemia Negatively Impacts Right Ventricular Function in Patients with HFpEF

HCPLive

Anemia in heart failure with preserved ejection fraction was linked to right ventricular dysfunction in an analysis of more than 1000 patients in China.

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5 NYC Health hospitals are hypertension control 'champions'

Becker's Hospital Review - Cardiology

The CDC and CMS added four NYC Health + Hospitals' facilities to the Million Hearts Hypertension Control Champion list in 2024, which recognizes hospitals who have achieved blood pressure control for at least 80% of adult hypertension patients.

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FDA Authorizes Predetermined Change Control Plan for Sleep Wearable Dreem 3S

HCPLive

Dreem 3S is the first sleep wearable with an FDA-authorized Predetermined Change Control Plan.

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10 recent cardiology partnerships

Becker's Hospital Review - Cardiology

"Discover the latest cardiology partnerships, from a $700 million investment in cardiovascular care to international AI applications, in this article.

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Dermatology Month in Review | November 2024

HCPLive

The November Month in Review features a set of dermatology news coverage highlights, including FDA news and developments in psoriasis.

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ACCEL Lite: Top Takeaways from 2024: Interventional Cardiology with Deepak L. Bhatt, MD, MPH, MBA, FACC

American College of Cardiology

In this interview, Deepak L Bhatt, MD, MPH, MBA, FACC, and Alison L. Bailey, MD FACC, discuss the Top Interventional Takeaways from 2024. Dr. Bhatt discusses the CLEAR SYNERGY, DanGer Shock, EARLY TAVR trials and more.

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Comparing the Latest Stool- Based and Blood-Based Colorectal Cancer Screening Tests

HCPLive

Vivek Kaul, MD, discusses the sensitivity and accuracy of the stool DNA test, providing relevant data, while also describing the role of blood-based tests in colorectal cancer screening and how they complement or differ from stool-based tests.

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Decongestion and Outcomes in Patients Hospitalized With Acute HF

American College of Cardiology

What is the prevalence and prognostic impact of decongestion in patients with acute heart failure (HF)?

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Protective effect of UDCA against IL-11- induced cardiac fibrosis is mediated by TGR5 signalling

Frontiers in Cardiovascular Medicine

IntroductionCardiac fibrosis occurs in a wide range of cardiac diseases and is characterised by the transdifferentiation of cardiac fibroblasts into myofibroblasts these cells produce large quantities of extracellular matrix, resulting in myocardial scar. The profibrotic process is multi-factorial, meaning identification of effective treatments has been limited.

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Predicting cardiac issues in cancer survivors using a serum protein panel test

Medical Xpress - Cardiology

Early disease detection is beneficial for securing the best possible outcomes for patients. But finding noninvasive, effective ways to predict disease risk is a tremendous challenge.

Cancer 45